Epigenetics meets estrogen receptor: regulation of estrogen receptor by direct lysine methylation
نویسندگان
چکیده
منابع مشابه
Maternal regulation of estrogen receptor a methylation
Advances in molecular biology have provided tools for studying the epigenetic factors that modulate gene expression. DNA methylation is an epigenetic modification that can have sustained effects on transcription and is associated with longterm gene silencing. In this review, we focus on the regulation of estrogen receptor alpha (ERa) expression by hormonal and environmental cues, the consequenc...
متن کاملEpigenetics and the estrogen receptor.
The position effect variegation in Drosophila and Schizosaccharomyces pombe, and higher-order chromatin structure regulation in yeast, is orchestrated by modifier genes of the Su(var) group, (e.g., histone deacetylases ([HDACs]), protein phosphatases) and enhancer E(Var) group (e.g., ATP [adenosine 5'-triphosphate]-dependent nucleosome remodeling proteins). Higher-order chromatin structure is r...
متن کاملSignificance of microRNA targeted estrogen receptor in male fertility
Objective(s): Estrogen receptor-alpha (ERα) mediates estrogen action in regulation of different levels of the hypothalamic-pituitary-testis axis. It has a key role in spermatogenesis. Estrogen receptor alpha knock-out (ER koα) male mice were infertile and severe impairment in spermatogenesis and seminiferous tubules was observed. Recently, it has been reported that microRNA (miRNA) mir-100 and ...
متن کاملEstrogen Receptor-A Methylation Predicts Melanoma Progression
The role of estrogen receptor A (ER-A) in melanoma is unknown. ER-A expression may be regulated in melanoma via hypermethylation of promoter CpG islands. We assessed ER-A hypermethylation in primary and metastatic melanomas and sera as a potential tumor progression marker. ER-A methylation status in tumor (n = 107) and sera (n = 109) from American Joint Committee on Cancer (AJCC) stage I to IV ...
متن کاملEstrogen Receptor Beta Expression in Melanomas Versus Dysplastic Nevi
Dear Editor-in-ChiefMalignant melanoma is a tumor arising from melanocyte; this tumor rarely occurs before puberty, with higher mortality rate in males and better survival rate in female patients affected by metastatic melanoma (1, 2). These facts propose that a relationship and association may exist between estrogens and melanoma. The effects of estrogens are mediated by...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2009
ISSN: 1351-0088,1479-6821
DOI: 10.1677/erc-08-0305